UMark Gurarie ungumbhali ozisebenzelayo, umhleli kanye nomfundisi wesikhashana ngokubhala eGeorge Washington University.
U-Anita Chandrasekaran, MD, Ingcweti Yezempilo Yomphakathi, egunyazwe yiBhodi Yezokwelapha Yangaphakathi NeRheumatology, okwamanje usebenza njengodokotela wamathambo e-Hartford Healthcare Medical Group e-Connecticut.
I-Gel-One (i-hyaluronate exhunywe ngokuphambana) iyindlela yokwelapha ye-knee osteoarthritis (OA).Lona umjovo osiza ukulawula ubuhlungu obuhlobene.
Itholakala kuphrotheni (i-hyaluronic acid) ekhishwa kumakhekhe ezinkukhu noma kumakhekhe.Umzimba womuntu ukhiqiza le protein ngokwemvelo ukuze ugcobe amalunga.Indima yayo ukubuyisela izinga laleli phrotheni.
I-Gel-One yaqala ukugunyazwa yi-US Food and Drug Administration (FDA) ngo-2001. Yahlolwa kuphela esivivinyweni somtholampilo futhi yabonakala iphumelela ekwehliseni amaphuzu ezinhlungu kuze kube amasonto ayi-13, kodwa ezinye iziphetho, okuhlanganisa ukuqina Nomzimba. umsebenzi, awukho umehluko wezibalo otholwe nge-placebo.
Alikho ikhambi eliphelele le-OA.Lokhu kwelashwa ngokuvamile kwenziwa kuphela ngemva kokuzama ezinye izindlela zokuphatha (njengokuphuza imithi noma ukulungisa indlela yokuphila).
Njenganoma yimuphi umuthi, umjovo we-Gel-One awunayo imiphumela emibi kanye nezingozi.Uma une-OA, kubalulekile ukwazi okuningi ngangokunokwenzeka mayelana nohlelo lwakho lokwelapha.
I-Gel-One ifanele i-knee OA, ebonakala ngokuguga nokudabuka, okubangela ubuhlungu.I-OA iwuhlobo oluvame kakhulu lwesifo samathambo, futhi nakuba singathinta noma ubani, sivame kakhulu kubantu abangaphezu kweminyaka engama-65.
Okokuqala, lapho ezinye izindlela zokwelapha (ezifana nokuthatha izidakamizwa ezingekho-steroidal ezilwa nokuvuvukala (NSAID) noma ukwelapha ngokomzimba) zingasebenzi, i-Gel-One izozanywa.Njengoba i-OA iyisifo esiqhubekayo futhi esingenakulungiseka, nakuba ukuhlinzwa kungase kube inketho, ukuyelapha ngokuvamile kusho ukulawula izimpawu.Lo mjovo umele ukwelashwa okungeziwe okuqinile.
Ngaphambi kokucabangela umjovo we-Gel-One njengokwelashwa, ukuhlonzwa okufanele kwe-OA kubalulekile.Indlela yokuhlola lesi simo?Lokhu ukuhlukaniswa okusheshayo:
Xoxa ngayo yonke imithi, izithasiselo, namavithamini owathathayo njengamanje nomhlinzeki wakho wokunakekelwa kwezempilo.Nakuba ezinye izidakamizwa zibeka engcupheni encane yokusebenzisana, ezinye izidakamizwa zingahle zivinjelwe ngokuphelele noma zisheshe zicabangele ukuthi izinzuzo nokulimala kokwelashwa kukhulu yini kunecala lakho.
Imikhiqizo ephuma ku-hyaluronic acid ethengiswa ngaphansi kwamagama afana ne-Restylane, i-Juvéderm ne-Perlane izigcwalisi zobuso ezisetshenziselwa ukushelela imibimbi noma izindebe eziminyene.Njengamalunga, amazinga e-hyaluronic acid azokwehla ngokukhula, okuholela ekuwohlokeni kwesikhumba.Ngokujova lezi ebusweni, isikhumba sizoqina.
Ngaphezu kwalokho, odokotela bamazinyo bangase basebenzise i-hyaluronic acid njengengxenye yohlelo lokwelapha ukuvuvukala kwezinsini okungapheli.Ngaphezu kwezinye izindlela zokwelapha, kuyasiza futhi ekunciphiseni ukuvuvukala kulezi zindawo futhi kusiza ekwelapheni i-gingivitis, periodontitis nezinye izinkinga.
Imijovo ye-Gel-One ilawulwa kuphela ngabahlinzeki bezempilo ezilungiselelweni zesibhedlela, futhi njengoba kushiwo ngenhla, akunconywa ukwenza lolu hlobo lokwelashwa izikhathi ezingaphezu kwesisodwa ngedolo ngalinye.Ipakishwe kusirinji yengilazi efakwe ngaphambili, egcwele amamililitha angu-3 (mL) ekhambi, equkethe amamiligremu angu-30 (mg) we-hyaluronic acid.
I-Seigaku Corporation, ekhiqiza i-Gel-One, kanye ne-FDA igcizelela ukuthi akunconywa ukuthatha izikhathi eziningi noma ukushintsha incwadi kadokotela.Kodwa-ke, uma ungaqiniseki, qiniseka ukuthi uxoxisana ngomthamo ofanele nodokotela wakho.
Nakuba ukuphatha nokugcina kuncike kumhlinzeki wakho wokunakekelwa kwezempilo, kubalulekile ukuqonda ukuthi lokhu kufanele kubukeke kanjani.Ukusetshenziswa okufanele kwe-Gel-One imi kanje:
Imiphumela emibi evame kakhulu yomjovo we-Gel-One ivame ukuxazulula;kodwa-ke, kufanele wazise umhlinzeki wakho wezempilo uma lezi zinkinga ziphikelela noma zenzeka.Zihlanganisa:
Ngemva kokwelashwa, sicela unake indlela ozizwa ngayo.Uma ucabanga ukuthi udinga usizo, sicela ungangabazi ukucela usizo.
Ukusabela okunamandla ku-Gel-One akuvamile futhi okuningi kubangelwa ukungezwani nezidakamizwa.Uma uhlangabezana nanoma yisiphi kulezi zimo ezilandelayo, sicela ufune usizo ngokushesha:
Isizathu sokuthi i-Gel-One ivame ukubekezelelwa ukuthi umuthi uphathwa umhlinzeki wezempilo, ngaleyo ndlela unciphisa ithuba lokudlula umthamo.Njengoba ngokuvamile unganikezwa izikhathi eziningi (okungenani edolweni elilodwa), ithuba lokusebenzisana okubi phakathi kwalo muthi neminye imithi oyisebenzisayo aphansi kakhulu.
Kodwa-ke, kubalulekile ukuthi uma isikhumba sakho sihlanzwe ngesibulala-magciwane se-quaternary ammonium, akufanele uthole imijovo ye-Gel-One.Izidakamizwa zingasabela ezixazululweni ezinjalo.
I-Casale M, i-Moffa A, i-Vella P, njll. I-Hyaluronic acid: ikusasa lamazinyo.ukuhlolwa kwesistimu.I-Int J Immunopathol Pharmacol.2016;29(4):572-582.
Isikhathi sokuthumela: Oct-19-2021