Ziningi izindlela zokunciphisa imigqa emihle nemibimbi, kodwa enye ephumelela kakhulu ukusebenzisa ama-neuromodulators.I-Dysport® (abobotulinumtoxinA) ingelinye lama-neurotoxin aziwa kakhulu emakethe.Kungumjovo kadokotela wabantu abadala abangaphansi kweminyaka engama-65 ubudala.Kufakazelwe ukuthi kusiza ukushelela okwesikhashana imigqa eswakene phakathi kwamashiya.Lena inkinga abaningi bethu abazama ukuyixazulula.
Njenganoma yimuphi umuthi, kunemiphumela emibi engaba khona.Ku-Dysport, imiphumela emibi evame kakhulu ukucasuka kwekhala nomphimbo, ikhanda elibuhlungu, ubuhlungu endaweni yomjovo, ukusabela kwesikhumba endaweni yomjovo, ukutheleleka komgudu wokuphefumula ongenhla, ukuvuvukala kwejwabu leso, amajwabu amehlo ashona phansi, i-sinusitis, nesicanucanu.(Ulwazi oluphelele olubalulekile lokuphepha, okuhlanganisa izexwayiso zebhokisi elimnyama mayelana nokudluliswa kwebanga elide kwemiphumela yobuthi, kuyatholakala ekupheleni kwalesi sihloko.)
Nakuba wonke umuntu azi ukuthi i-Dysport ingabushelela imibimbi, ineminye imisebenzi eminingi.Lapha, sihlukanise amaqiniso ayi-10 abalulekile mayelana nemijovo ukuze ukwazi ukunquma ukuthi ikulungele yini.
I-Dysport iphatha okwesikhashana imigqa eshwabene phakathi kwamashiya ngokunciphisa umsebenzi othile wemisipha, ngoba imibimbi ibangelwa ukuvivinya umzimba okuphindaphindiwe nokufinyela kwemisipha.1 Umjovo owodwa emaphoyintini amahlanu phakathi nangaphezulu kwamashiya ungavimbela okwesikhashana ukufinyela kwemisipha okubangela imigqa eshwabene.Njengoba kunokunyakaza okuncane endaweni, imigqa ayinakwenzeka ukuthuthukisa noma ukujula.
Ngokwemibiko, iDysport ingaveza imiphumela ezinsukwini ezimbili kuya kwezintathu kuphela ngemuva kokwelashwa okuyimizuzu eyi-10 kuye kwengama-20.I-2-4 Lokhu kunikeza ukuguquguquka okwengeziwe ezigulini ezidinga imiphumela lapho zihlela amalungiselelo ezimonyo emicimbini noma imibuthano yokuzijabulisa.
I-Dysport ayigcini nje ngokuqala ngokushesha, * 2-4, kodwa futhi ihlala isikhathi eside.Eqinisweni, iDysport ingahlala izinyanga ezinhlanu.† 2,3,5.
* Isiphetho sesibili sisekelwe esilinganisweni sika-Kaplan-Meier sesilinganiso sesikhathi esiqongelelwe sokuphendula.I-GL-1 (Dysport 55/105 [52%], placebo 3/53 [6%]) ne-GL-2 (Dysport 36/71 [51%], placebo 9/71 [13%]) kanye ne-GL- izinsuku ezingu-32 (Dysport 110/200 [55%], placebo 4/100 [4%]).† I-GL-1 ne-GL-3 zihlolwe izifundo okungenani izinsuku eziyi-150 ngemuva kokwelashwa.Ngokusekelwe ekusetshenzisweni kwedatha evela kuzifundo ezimbili ezibalulekile ezingaboni kabili, ezingahleliwe, ezilawulwa yi-placebo (i-GL-1, i-GL-3) ekuhlaziyweni kwe-post-hoc, i-GLSS ithuthukiswe ≥ ileveli 1 kusukela kwesisekelo.
"Nge-Dysport-kanye nama-syringe ochwepheshe-kufanele ulindele lokho esikubiza ngokuthi ukuthambisa imibimbi eguquguqukayo: imibimbi eyakha ngokunyakaza kwemisipha nokufinyela," kuchaza u-Omer Ibrahim, MD, udokotela wesikhumba waseChicago.“Kufanele ulindele ukuthamba kwemigqa enwebekayo emaphakathi kuya kokuqina kuyilapho ugcina ukubukeka kwakho kwemvelo, kweqiniso.”
"I-Dysport ingase ingakwazi ukususa ngokuphelele imibimbi ejulile ye-static, okuyimibimbi ekhona lapho uphumula ngaphandle kokuvinjelwa kwemisipha," kusho uDkt Ibrahim.Le migqa ejulile ebonakalayo lapho ubuso buphumule ngokuvamile idinga ukwelashwa okujulile kwasehhovisi ukuze kuthuthukiswe ukubukeka kwayo."Yebo, i-Dysport ayikwazi ukusetshenziswa njenge-filler, okusho ukuthi ngeke kusize imifantu ejulile yobuso kanye nokucindezeleka okufana nama-cheekbones, izindebe nemigqa yokumamatheka," kusho uDkt Ibrahim.
I-Dysport ifakazelwe ngokukhethekile ukuthi iyasebenza ekuthuthukiseni okwesikhashana ukubukeka kwemibimbi endaweni yokukhathazeka okuvamile: phakathi kwamashiya.Uma ingelashwa, le migqa eshwabene phakathi kwamashiya ingenza abantu babukeke bethukuthele futhi bekhathele.
Ukuze unciphise ukufinyela kwemisipha ethile okungabangela imigqa emihle nemibimbi phakathi kwamashiya, isirinji yakho izojova i-Dysport ezindaweni eziqondile ezinhlanu: umjovo owodwa phakathi kwamashiya nemijovo emibili ngaphezu kweshiya ngalinye.
Njengoba kusetshenziswa amaphuzu amahlanu kuphela womjovo, ukwelashwa kweDysport kuyashesha kakhulu.Yonke inqubo ithatha kuphela imizuzu eyi-10 kuye kwengama-20.Eqinisweni, kuyashesha kangangokuthi ungakwazi ngisho nokwenza i-aphoyintimenti ngesikhathi sakho sekhefu lasemini ngoba akudingekile ukuba ukhathazeke ngokushiya umsebenzi isikhathi eside kakhulu.
"Izindaba ezinhle ukuthi abantu abaningi bangabalungele iDysport," kusho uDkt. Ibrahim.Indlela engcono kakhulu yokwazi ukuthi ingabe lokhu kwelashwa kukulungele yini ukuxoxa ngeDysport nomhlinzeki wakho.Uma ungezwani namaprotheni obisi noma enye ingxenye ye-Dysport, ungezwani nanoma iyiphi i-neuromodulator nanoma iyiphi enye ingxenye, noma unokutheleleka endaweni ehleliwe yomjovo, i-Dysport akuyona eyakho.UDkt. Ibrahim wanezela: “Abantu okufanele bagweme i-Dysport yilabo okwamanje abakhulelwe, abancelisayo, abangaphezu kweminyaka engu-65, noma abanobuthakathaka obukhulu bemisipha nezinye izifo zezinzwa.”
"I-Dysport isetshenziselwe ukuqeda imibimbi yobuso iminyaka eminingi, futhi ukuphepha nokusebenza kwayo kuye kwafakazelwa ezifundweni nasezigulini emhlabeni jikelele6," uDkt Ibrahim uqinisekisile."Ezandleni ezifanele, iDysport izokhiqiza imiphumela ecashile, yemvelo."
I-Dysport® (abobotulinumtoxinA) iwumjovo kadokotela osetshenziselwa ukuthuthukisa okwesikhashana ukubukeka kwemigqa eshwabene emaphakathi kuya kokuqina (imigqa ephakathi kwamashiya) phakathi kwamashiya abantu abadala abangaphansi kweminyaka engama-65 ubudala.
Iluphi ulwazi olubaluleke kakhulu okufanele ukwazi ngeDysport?Ukusabalala kwemiphumela yobuthi: Kwezinye izimo, imiphumela ye-Dysport nayo yonke imikhiqizo yobuthi be-botulinum ingase ithinte izindawo zomzimba ezikude nendawo yomjovo.Izimpawu zingase zenzeke emahoreni ambalwa kuya emasontweni ngemva komjovo futhi zingase zihlanganisa izinkinga zokugwinya nokuphefumula, ubuthakathaka obuvamile nobuthakathaka bemisipha, ukubona kabili, ukungaboni kahle nokuwa kwamajwabu amehlo, ukuhhewula noma ukushintsha noma ukulahlekelwa izwi, ubunzima bokukhuluma ngokucacile, noma ukulahlekelwa ukulawula isinye. .Izinkinga zokugwinya nokuphefumula zingasongela ukuphila, futhi kubikwe nokufa.Uma lezi zinkinga bezikhona ngaphambi komjovo, usengozini enkulu kakhulu.
Le miphumela ingase ikwenze kungaphephile kuwe ukushayela imoto, ukusebenzisa imishini, noma ukwenza ezinye izinto eziyingozi.
Ungatholi ukwelashwa kwe-Dysport uma une: i-allergies ku-Dysport noma noma yiziphi izithako zayo (bheka uhlu lwezithako ekupheleni komhlahlandlela wezidakamizwa), ukungezwani komzimba kumaprotheni obisi, ukungezwani komzimba kunoma yimiphi eminye imikhiqizo ye-toxin ye-botulinum, njenge-Myobloc®, I-Botox® noma i-Xeomin®, inokutheleleka kwesikhumba endaweni ehleliwe yomjovo, ingaphansi kweminyaka engu-18 ubudala, noma ikhulelwe noma incela ibele.
Umthamo we-Dysport uhlukile kumthamo wanoma yimuphi omunye umkhiqizo wobuthi be-botulinum futhi awunakuqhathaniswa nomthamo wanoma yimuphi omunye umkhiqizo okungenzeka ukuthi uwusebenzisile.
Tshela udokotela wakho nganoma ibuphi ubunzima bokugwinya noma bokuphefumula kanye nazo zonke izimo zemisipha noma zezinzwa zakho, njenge-amyotrophic lateral sclerosis [ALS noma isifo sika-Lou Gehrig], i-myasthenia gravis noma i-Lambert-Eaton syndrome, engandisa ingozi yemiphumela emibi kakhulu , Kuhlanganisa nobunzima. ukugwinya nokuphefumula ubunzima.Ukungezwani okukhulu komzimba kungenzeka uma usebenzisa iDysport.Kubikwe namehlo omile.
Tshela udokotela wakho ngazo zonke izimo zakho zezokwelapha, okuhlanganisa noma kukhona izinguquko zokuhlinzwa ebusweni bakho, imisipha endaweni yokwelapha ibuthakathaka kakhulu, kungakhathaliseki ukuthi kukhona izinguquko ezingavamile ebusweni, ukuvuvukala endaweni yomjovo, amajwabu amehlo ashona noma ijwabu leso eligobile. ukugoqa, izibazi ezijulile ebusweni, isikhumba esinamafutha amaningi, imibimbi engakwazi ukushelela ngokuyihlukanisa, noma uma ukhulelwe noma uncelisa noma uhlela ukukhulelwa noma ukuncelisa.
Tshela udokotela wakho ngayo yonke imithi oyiphuzayo, okuhlanganisa nemithi kadokotela kanye ne-over-the-counter, amavithamini, amakhambi, neminye imikhiqizo yemvelo.Ukusebenzisa i-Dysport neminye imithi ethile kungase kubangele imiphumela emibi kakhulu.Lapho uthatha i-Dysport, ungaqali noma yimiphi imithi emisha ngaphandle kokubonisana nodokotela wakho kuqala.
Ikakhulukazi, tshela udokotela wakho uma unalezi zimo ezilandelayo: Phakathi nezinyanga ezine ezedlule noma nganoma isiphi isikhathi esidlule (qiniseka ukuthi udokotela wakho wazi kahle ukuthi yimuphi umkhiqizo owutholile, imijovo yakamuva yama-antibiotic, iziphumuza imisipha , Thatha i-allergies noma imithi ebandayo. noma uphuze amaphilisi okulala.
Imiphumela engemihle evame kakhulu ukucasuka kwekhala nomphimbo, ikhanda elibuhlungu, ubuhlungu lapho umjovo, ukusabela kwesikhumba endaweni yomjovo, ukutheleleka komgudu wokuphefumula ongenhla, ukuvuvukala kwejwabu leso, amajwabu amehlo axegayo, i-sinusitis, nesicanucanu.
Isikhathi sokuthumela: Aug-23-2021