I-FRANKFURT, Germany–(BUSINESS WIRE)–Merz Therapeutics, umholi emkhakheni we-neurotoxins kanye nebhizinisi ngaphansi kwe-Merz Group, kanye ne-Teijin Pharma Limited, inkampani eyinhloko yebhizinisi lezempilo le-Teijin Group, bamemezele ngokuhlanganyela namuhla ukuthi i-Teijin Pharmaceuticals iwine Ukwengeza. imvume evela ku-Ministry of Health, Labor and Welfare yase-Japan (MHLW) ukusebenzisa i-Xeomin® (incobotulinumtoxinA) kumayunithi angama-50, ayi-100 noma angu-200 omjovo we-intramuscular for the treatment of the lower spasms.
I-spasm yemilenze engezansi kuwuphawu lwe-upper motor neuron syndrome, ebonakala ngokuyinhloko ngokukhuphuka kwethoni yemisipha yemilenze kanye nenjabulo eyeqile ye-stretch reflex njenge-sequelae ye-stroke.Izimpawu eziyinhloko ziwubunzima bokuhamba ngokujwayelekile kanye nengozi eyengeziwe yokuwa ngenxa ye-trunk engazinzile, imisebenzi eyinkimbinkimbi noma evimbile ekuphileni kwansuku zonke.Ukwelashwa okuvamile kwama-spasms emilenzeni kuhlanganisa ukuvuselelwa ngokomzimba kanye nokusetshenziswa kwezidambisi mzimba zomlomo noma izivimba ze-neuromuscular, ezifana ne-botulinum toxin uhlobo A.
UStefan Brinkmann, oyi-CEO ye-Merz Therapeutics, uthe: “Ukugunyazwa okweluliwe kuphawula ingqopha-mlando ebalulekile kwe-Merz Therapeutics futhi kuwumphumela wokubambisana kwethu eduze ne-Teijin Pharmaceuticals.Sithemba ukuthi ozakwethu bazokwethula ngempumelelo lesi sibonakaliso esibalulekile se-spasticity kodokotela baseJapan neziguli. ”
UDkt. Stefan Albrecht, Iphini Likamongameli Omkhulu we-Global R&D, Merz Therapeutics: “Lokhu kunwetshwa kwelebula e-Japan kungesinye isibonelo esivelele sezinzuzo i-Xeomin ® ezinikeza iziguli eziningi ezine-spasticity yangemva kokushaywa unhlangothi.Odokotela manje sebengakhetha ukwelapha i-spasticity ephansi nangaphezulu, noma bangavumelana nezimo njengoba kudingeka. Sebenzisa imithamo ngayinye ngokucophelela.Siyaziqhenya ngale mpumelelo, ikakhulukazi ukubambisana okuhle kakhulu nozakwethu uTeijin.”
UMongameli we-Teijin Pharmaceutical u-Ichiro Watanabe uthe: “I-Teijin Pharmaceutical ihlinzeka ngemithi ehlukahlukene, okuhlanganisa ukwelashwa kwe-osteoporosis kanye nemishini yezokwelapha, njengegagasi lomsindo elisheshisa uhlelo lokuphulukisa ukuphuka kweziguli ezinezifo ze-musculoskeletal.Ukuphendula izinguquko zezibalo kanye nokuqwashisa okwengeziwe ngezempilo , Sethula imithi emisha esebenzayo nezisombululo, okuhlanganisa ukugcwaliseka komphakathi ozinzile.I-Teijin Pharmaceuticals iyaqhubeka nokubamba iqhaza ekuthuthukiseni izinga lempilo (QOL) yeziguli ngokuhlinzeka ngezinketho ezintsha zokwelapha izifo ezinezidingo ezingafinyeleleki.”
I-Xeomin® iphatha ngempumelelo iziphetho ze-peripheral cholinergic nerve ngokwenza buthaka ukufinyela kwemisipha yokuzithandela, futhi ikhulule ukungezwani kwemisipha ngokuvimbela ukukhululwa kwe-neurotransmitter ebizwa ngokuthi i-acetylcholine.I-neurotoxin ehlanzeke kakhulu iwukuphela kwesithako esisebenzayo ku-Xeomin®.Yenziwa ngokukhipha amaprotheni ayinkimbinkimbi ohlotsheni lwe-botulinum toxin ekhiqizwa i-Clostridium botulinum kusetshenziswa ubuchwepheshe bokuhlanza obuthuthukiswe yi-Merz Pharma GmbH & Co. KGaA.Ukuntuleka kwamaprotheni ayinkimbinkimbi kuvumela i-Xeomin® ukunciphisa ukukhiqizwa kwama-antibodies anganciphisa amandla anganciphisa ukusebenza kahle.Ukuthuthuka okuphawulekayo kumphumela we-plantar flexor modified ashworth scale (MAS) kubonwe esivivinyweni somtholampilo sesigaba sesi-III e-Japan.
I-Xeomin® isatshalaliswa ngabakwa-Merz Pharmaceuticals GmbH emazweni angaphezu kuka-70 futhi isetshenziselwa ukwelapha iziguli ezinemilenze engenhla, i-dystonia yomlomo wesibeletho, i-blepharospasm noma amathe ngokweqile.I-Teijin Pharmaceuticals isayine ilayisense elikhethekile kanye nesivumelwano sokuthuthukisa esihlanganyelwe se-Xeomin® e-Japan ne-Merz ngo-2017, futhi yaqala ukuthengisa okukhethekile kwe-Xeomin® ngo-December 2020 ngemva kokuthola imvume ku-Ministry of Health, Labour and Welfare (MHLW) yase-Japan.Ngokusekelwe ocwaningweni lomtholampilo lwe-Merz's Phase III e-Japan, ukugunyazwa okwengeziwe okusanda kutholwa kuguqule ezinye zezimvume ezigunyaziwe.
Ngokuvamile, kubantu abadala, i-Xeomin® kufanele ijovwe emisipha eminingi eqinile.*Umthamo omkhulu wokuphatha ngakunye ungamayunithi angama-400, kodwa kufanele wehliswe ngokufanelekile ube umthamo omncane ngokuya ngohlobo kanye nenani lemisipha ye-tonic eqondiwe.Uma umphumela womthamo wangaphambilini uncipha, phinda imithamo evunyelwe.Isikhathi sokudosa kufanele sibe amaviki ayi-12 noma ngaphezulu, kodwa singafushaniswa sibe amaviki ayi-10 kuye ngezimpawu.
* I-Myotonic: i-gastrocnemius (ikhanda eliphakathi, ikhanda elingemuva), i-soleus, i-posterior tibialis, i-flexor digitorum longus, njll.
I-Merz Therapeutics yibhizinisi le-Merz Pharmaceuticals GmbH elinikezelwe ukuthuthukisa izimpilo zeziguli emhlabeni jikelele.Ngocwaningo lwayo olungapheli, ukuthuthukiswa kanye nesiko lokusungula, i-Merz Therapeutics ilwela ukuhlangabezana nezidingo zesiguli ezingahlangatshezwana nazo futhi ithole imiphumela engcono.I-Merz Therapeutics ifuna ukuhlangabezana nezidingo eziyingqayizivele zabantu abahlushwa ukuphazamiseka kokunyakaza, izifo zemizwa, izifo zesibindi, nezinye izimo zezempilo ezithinta kakhulu izinga lempilo yeziguli.I-Merz Therapeutics ikomkhulu layo eliseFrankfurt, eJalimane, inamahhovisi abameleli emazweni angaphezu kuka-90, kanye negatsha laseNyakatho Melika eRaleigh, eNyakatho Carolina.I-Merz Pharmaceuticals GmbH iyingxenye ye-Merz Group, inkampani ephethwe ngasese ephethwe umndeni esizibophezele ekuthuthukiseni izinto ezintsha ezihlangabezana nezidingo zeziguli namakhasimende iminyaka engaphezu kwe-110.
I-Teijin (ikhodi ye-Tokyo Stock Exchange: 3401) iyiqembu lomhlaba jikelele eliqhutshwa ubuchwepheshe elihlinzeka ngezixazululo ezithuthukisiwe emkhakheni wezemvelo;ukuphepha, ukuphepha, kanye nokunciphisa izinhlekelele;kanye nezinguquko zezibalo kanye nokwanda kokuqwashisa ngezempilo.I-Teijin yasungulwa ngo-1918 njengomkhiqizi wokuqala we-rayon eJapane, futhi manje isithuthuke yaba ibhizinisi eliyingqayizivele elihlanganisa izindawo ezintathu zebhizinisi: izinto ezisebenza kahle ezihlanganisa i-aramid, i-carbon fiber nezinto eziyinhlanganisela, kanye ne-resin ne-plastic processing, Ifilimu. , i-polyester fiber kanye nokucubungula umkhiqizo;ukunakekelwa kwezokwelapha, okuhlanganisa imithi kanye nemishini yezempilo yasekhaya yamathambo/amalunga, isistimu yokuphefumula, kanye nezifo zenhliziyo nemithambo yegazi, ukuhlengikaza kanye nokunakekelwa kwangaphambi kwezimpawu;kanye ne-IT, okuhlanganisa izixazululo zezokwelapha, zebhizinisi kanye ne-B2B zezinhlelo zomphakathi, kanye nesofthiwe epakishiwe kanye nezinsizakalo ze-inthanethi ze-B2C zokuzijabulisa kwedijithali.Njengoba kuvezwe esitatimendeni somkhiqizo esithi "I-Human Chemistry, Human Solutions", i-Teijin izinikele ngokujulile kubabambiqhaza bayo futhi ihlose ukuba inkampani esekela umphakathi wesikhathi esizayo.Leli qembu lakhiwe izinkampani ezingaphezu kuka-170 futhi linabasebenzi abangaba ngu-20,000 emazweni/ezifundeni ezingu-20 emhlabeni jikelele.Onyakeni wezimali ophela ngoMashi 31, 2021, uTeijin umemezele ukuthengiswa okuhlanganisiwe kwama-yen ayizigidi eziyizinkulungwane ezingama-836.5 (amaRandi ayizigidi eziyizinkulungwane ezingama-7.7) kanye nempahla ephelele yama-yen ayizigidi eziyizinkulungwane eziyi-1.036.4 (amaRandi ayizigidi eziyizinkulungwane ezingama-9.5).
Isikhathi sokuthumela: Sep-10-2021